NIH-NIDDK PCOS Research Study – Bethesda, MD


This study is not affiliated with PCOS Challenge, Inc.
The announcement below is being provided for informational purposes only.

Researchers at the National Institutes of Health (NIH) are recruiting for a study on PCOS located at the NIH Clinical Center in Bethesda, Maryland.

Study Title

Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta 3-Adrenergic Receptor Agonists

Study Description

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder among women of reproductive age and is associated with infertility, skin problems, depression, and insulin resistance.

Brown adipose tissue (BAT) is a type of fat in the body. It may help prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if a commercially available medication, shown to increase the amount and activity of BAT in adult humans, can improve insulin sensitivity in women diagnosed with PCOS and insulin resistance.

Goals of the Study

  • To learn if a certain medication, mirabegron (Myrbetriq®), can improve insulin sensitivity in women diagnosed with PCOS.
  • To see how active BAT affects insulin sensitivity and overall health in women with PCOS.
PCOS Research Study - NIH-NIDDK

Apply for Research Study

You may be eligible to participate if you are:

  • Female
  • Age: 18-40 years old
  • Weight: BMI 20-45
  • Diagnosed with PCOS
  • Using birth control (IUD, implant or hormonal)

You are not eligible to participate if you:

  • Have Type 1 or Type 2 diabetes, hypertension, heart disease
  • Have been pregnant, given birth, or have been breastfeeding in the last 12 months
  • Are allergic to mirabegron or a similar drug
  • Drink more than 2 drinks per day or use nicotine
  • Spend more than 70% of your daily hours outside

What to Expect

  • 4 sets of overnight stays in NIH Clinical Center (4 days, 3 nights each = 16 days overall); meals included; all rooms have NIH-supported Wifi
  • 5 outpatient visits
  • Medical supervision will be provided throughout entire study by a doctor or nurse practitioner.
  • Regular bloodwork, EKGs, outpatient safety visits, and weekly check-ins to check for any adverse events


National Institutes of Health
9000 Rockville Pike
Bethesda, MD 20892


Earn up to $3,470 for participation

Principal Investigator

Aaron Cypess, MD, PhD

Where to Go For Further Information and
How to Apply

Apply for Research Study


This study is not affiliated with PCOS Challenge, Inc. PCOS Challenge, Inc. does not recommend or endorse any specific studies, tests, physicians, products, procedures, opinions, or other information from third parties that may be mentioned on the PCOS Challenge websites. Any such mention is for information purposes only. Any third party services, products and websites, including those offered by affiliates, sponsors and advertisers, which may be accessed through the PCOS Challenge websites are the sole responsibility of the third party who is offering the service, product or posting the website. PCOS Challenge, Inc. makes no warranty as to the accuracy of any information on third-party websites and accepts no liability for any claims, errors, and omissions or for any damage or injury to persons or property arising out of the use or operation of any services, products, materials, instructions, methods, ideas or procedures provided by third parties. Any offers, pricing, and/or promotions offered through the PCOS Challenge websites, affiliates, or any third party are subject change without notice at the sole discretion of the party making the offer. Read Full Disclaimer.

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